COMPARATIVE STUDY OF DIFFERENT BRANDS OF RANITIDINE TABLETS IN BANGLADESH

Abstract

Ranitidine is a H2- receptor blocker, which is widely used for the treatment of peptic ulcer disease. Present was designed to assess the therapeutic properties of different branded ranitidine hydrochloride tablets available in retail pharmacies of Bangladesh. Ranitidine HCl tablets manufactured by five different brands following USP specifications were collected from local retail Pharmacy located in Dhaka. Various parameters such as weight variation, thickness, hardness, disintegration, dissolution, potency etc. were analyzed according to the official (BP/USP8) pharmacopoeia methods to evaluate their quality. The result showed that four brands of Ranitidine HCl tablets complied USP specification of potency and the remaining one was more potent. Four brands showed a good result for weight variation, hardness, disintegration time and dissolution rate. One brand of tablets showed minor deviation in dissolution rate as compared to USP specification. It is evident from the study that most of the brands tested showed good results. Though this study was performed on a limited scale but the data reported here can help the Drug Control Authority to get an idea a